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Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities

Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities

July 14, 2025 Category: Blog

Background Subclassification of ovarian carcinomas can be used to guide treatment and determine prognosis.Germline and somatic mutations, loss of heterozygosity (LOH), and epigenetic events such as promoter hypermethylation can lead to decreased expression of BRCA1/2 in ovarian cancers.The mechanism of BRCA1/2 loss is a potential method of subclass

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Engaging Primary Care Physicians to Refer Patients to Home-Based Palliative Is Challenging and Complicated

July 14, 2025 Category: Blog

Background: Before the Affordable Care Act (ACA), the financing landscape for fee-for-service health care lacked broad structure and incentives to provide palliative care outside hospitals.Since the ACA, several payers have taken the opportunity to offer home-based palliative care (HBPC) to their members.Objective: To evaluate the impact of outreac

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